Product Data Sheet
DN-108
Catalog No. A40145
DN-108 is a thiazolidinedione derivative that serves as an orally active agonist for peroxisome proliferator-activated receptor γ (PPARγ). This compound exhibits notable antidiabetic properties, effectively improving hyperglycemia, hypertriglyceridemia, and hyperinsulinemia in diabetic mouse models. DN-108 enhances glucose uptake in tissues, such as increasing 2-deoxyglucose uptake in L6 muscle cells, and inhibits fatty acid synthase activity. This makes DN-108 a valuable tool for research focused on type 2 diabetes.
Chemical Information
| Catalog Num | A40145 |
|---|---|
| M. Wt | 366.43 |
| Formula | C20H18N2O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 195604-21-8 |
| Synonyms | |
| SMILES | O=C1SC(CC2=CC=C(NC(C3(CC3)C4=CC=CC=C4)=O)C=C2)C(N1)=O |
Biological Activity
| Description | DN-108 is a thiazolidinedione derivative that serves as an orally active agonist for peroxisome proliferator-activated receptor γ (PPARγ). This compound exhibits notable antidiabetic properties, effectively improving hyperglycemia, hypertriglyceridemia, and hyperinsulinemia in diabetic mouse models. DN-108 enhances glucose uptake in tissues, such as increasing 2-deoxyglucose uptake in L6 muscle cells, and inhibits fatty acid synthase activity. This makes DN-108 a valuable tool for research focused on type 2 diabetes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
