Product Data Sheet
VSP-77
Catalog No. A40147
VSP-77 is an orally active PPARγ agonist that enhances insulin sensitivity by inhibiting CDK5-mediated phosphorylation of PPARγ at Ser-273. This mechanism leads to the upregulation of key genes such as Glut4 and Adiponectin, which are crucial for glucose metabolism. In high-fat diet-induced diabetic mouse models, VSP-77 significantly improves glucose tolerance and lowers fasting blood glucose and insulin levels. It serves as a valuable reagent for studying diabetes and its associated metabolic pathways.
Chemical Information
| Catalog Num | A40147 |
|---|---|
| M. Wt | 298.81 |
| Formula | C16H23ClO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1854008-12-0 |
| Synonyms | |
| SMILES | ClC1=CC=C(C(CCCCCCC)OCC(O)=O)C=C1 |
Biological Activity
| Description | VSP-77 is an orally active PPARγ agonist that enhances insulin sensitivity by inhibiting CDK5-mediated phosphorylation of PPARγ at Ser-273. This mechanism leads to the upregulation of key genes such as Glut4 and Adiponectin, which are crucial for glucose metabolism. In high-fat diet-induced diabetic mouse models, VSP-77 significantly improves glucose tolerance and lowers fasting blood glucose and insulin levels. It serves as a valuable reagent for studying diabetes and its associated metabolic pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
