Product Data Sheet
PPARδ agonist 9
Catalog No. A40155
PPARδ Agonist 9 is a potent agonist of the peroxisome proliferator-activated receptor delta (PPARδ), exhibiting an EC50 of 3.6 nM. This compound demonstrates significant in vivo efficacy, evidenced by its ability to lower serum levels of MCP-1 in murine models. Additionally, PPARδ Agonist 9 effectively inhibits the progression of atherosclerosis in the LDL receptor knockout mouse model, achieving an inhibition rate of 50-60%. This makes it a valuable tool for research into metabolic disorders and cardiovascular diseases.
Chemical Information
| Catalog Num | A40155 |
|---|---|
| M. Wt | 569.04 |
| Formula | C26H28ClF3N4O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 928023-21-6 |
| Synonyms | |
| SMILES | ClC1=CC(CC(O)=O)=CC(OCCC2(N3CCCC3)CCN(C4=NC5=CC=C(N=C5S4)C(F)(F)F)CC2)=C1 |
Biological Activity
| Description | PPARδ Agonist 9 is a potent agonist of the peroxisome proliferator-activated receptor delta (PPARδ), exhibiting an EC50 of 3.6 nM. This compound demonstrates significant in vivo efficacy, evidenced by its ability to lower serum levels of MCP-1 in murine models. Additionally, PPARδ Agonist 9 effectively inhibits the progression of atherosclerosis in the LDL receptor knockout mouse model, achieving an inhibition rate of 50-60%. This makes it a valuable tool for research into metabolic disorders and cardiovascular diseases. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
