Product Data Sheet
PPARδ agonist 13
Catalog No. A40161
PPARδ Agonist 13 is a highly selective and potent agonist for the peroxisome proliferator-activated receptor delta (PPARδ), demonstrating an EC50 of 0.50 nM. By binding to the PPARδ ligand-binding pocket, it effectively upregulates the expression of PPARδ target genes. This compound inhibits renal fibroblast activation, restores fatty acid oxidation, and mitigates TGF-β1-induced renal fibroblast activation, showcasing its anti-fibrotic effects in a mouse model of unilateral ureteral obstruction. PPARδ Agonist 13 serves as a valuable tool for investigating the mechanisms of renal fibrosis.
Chemical Information
| Catalog Num | A40161 |
|---|---|
| M. Wt | 520.48 |
| Formula | C27H24F3N2NaO4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3056618-93-7 |
| Synonyms | |
| SMILES | O=C(CCCCCOC1=C(CN2C(C3=CC=C(C=C3)OC(F)(F)F)=NC4=C2C=CC=C4)C=CC=C1)O[Na] |
Biological Activity
| Description | PPARδ Agonist 13 is a highly selective and potent agonist for the peroxisome proliferator-activated receptor delta (PPARδ), demonstrating an EC50 of 0.50 nM. By binding to the PPARδ ligand-binding pocket, it effectively upregulates the expression of PPARδ target genes. This compound inhibits renal fibroblast activation, restores fatty acid oxidation, and mitigates TGF-β1-induced renal fibroblast activation, showcasing its anti-fibrotic effects in a mouse model of unilateral ureteral obstruction. PPARδ Agonist 13 serves as a valuable tool for investigating the mechanisms of renal fibrosis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
