Product Data Sheet
8(9)-EET ((8S,9R)-EET)
Catalog No. A40184
8(9)-EET is an arachidonic acid metabolite produced through the cytochrome P450 epoxide pathway. It serves as an effective substrate for cyclooxygenases COX-1 and COX-2 and exhibits significant biological activity by activating PPARα in HEK293 cells. Additionally, 8(9)-EET inhibits NF-κB activity induced by IL-1β, functioning both in a PPARα-dependent and -independent manner. The (8S,9R)-isomer of 8(9)-EET specifically induces vasoconstriction, leading to reduced renal plasma flow and glomerular filtration rate, making it a relevant compound for studies in renal and cardiovascular research.
Chemical Information
| Catalog Num | A40184 |
|---|---|
| M. Wt | 320.47 |
| Formula | C20H32O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 82864-43-5 |
| Synonyms | |
| SMILES | CCCCC/C=C\C/C=C\C[C@H]1[C@H](O1)C/C=C\CCCC(O)=O |
Biological Activity
| Description | 8(9)-EET is an arachidonic acid metabolite produced through the cytochrome P450 epoxide pathway. It serves as an effective substrate for cyclooxygenases COX-1 and COX-2 and exhibits significant biological activity by activating PPARα in HEK293 cells. Additionally, 8(9)-EET inhibits NF-κB activity induced by IL-1β, functioning both in a PPARα-dependent and -independent manner. The (8S,9R)-isomer of 8(9)-EET specifically induces vasoconstriction, leading to reduced renal plasma flow and glomerular filtration rate, making it a relevant compound for studies in renal and cardiovascular research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
