Product Data Sheet
4-Oxo Docosahexaenoic Acid
Catalog No. A40192
4-Oxo Docosahexaenoic Acid is a potent PPARγ agonist with notable antiproliferative properties. This compound effectively inhibits the growth of several triple-negative breast cancer cell lines, such as MDA-MB-231 and BT549, at concentrations of 50-100 μM, although it shows increased proliferation in MCF-7 cells. It covalently binds to PPARγ, activating gene transcription, as demonstrated in luciferase reporter assays and dendritic cells, with an EC50 of approximately 8-16 μM. This makes 4-Oxo DHA a valuable tool for research into cancer biology and PPARγ-associated pathways.
Chemical Information
| Catalog Num | A40192 |
|---|---|
| M. Wt | 342.47 |
| Formula | C22H30O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 845673-74-7 |
| Synonyms | 4-oxo DHA |
| SMILES | CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C=C\C(CCC(O)=O)=O |
Biological Activity
| Description | 4-Oxo Docosahexaenoic Acid is a potent PPARγ agonist with notable antiproliferative properties. This compound effectively inhibits the growth of several triple-negative breast cancer cell lines, such as MDA-MB-231 and BT549, at concentrations of 50-100 μM, although it shows increased proliferation in MCF-7 cells. It covalently binds to PPARγ, activating gene transcription, as demonstrated in luciferase reporter assays and dendritic cells, with an EC50 of approximately 8-16 μM. This makes 4-Oxo DHA a valuable tool for research into cancer biology and PPARγ-associated pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
