Product Data Sheet
Naphthol AS-MX phosphate
Catalog No. A40307
Naphthol AS-MX phosphate is an inhibitor of the CREB-CBP transcription factor complex, functioning to disrupt its activity. This compound exhibits significant antitumor effects against lung cancer cells, demonstrating an IC50 value of 3.701 μmol/L for inhibiting cell proliferation, as well as reducing colony formation and anchorage-independent growth in soft agar assays. Naphthol AS-MX phosphate serves as a valuable tool for research on KRAS-mutated lung cancer, particularly in instances characterized by poor chemotherapy resistance and unfavorable prognoses.
Chemical Information
| Catalog Num | A40307 |
|---|---|
| M. Wt | 371.32 |
| Formula | C19H18NO5P |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1596-56-1 |
| Synonyms | NASTRp |
| SMILES | O=C(C1=C(OP(O)(O)=O)C=C2C=CC=CC2=C1)NC3=CC=C(C)C=C3C |
Biological Activity
| Description | Naphthol AS-MX phosphate is an inhibitor of the CREB-CBP transcription factor complex, functioning to disrupt its activity. This compound exhibits significant antitumor effects against lung cancer cells, demonstrating an IC50 value of 3.701 μmol/L for inhibiting cell proliferation, as well as reducing colony formation and anchorage-independent growth in soft agar assays. Naphthol AS-MX phosphate serves as a valuable tool for research on KRAS-mutated lung cancer, particularly in instances characterized by poor chemotherapy resistance and unfavorable prognoses. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
