Product Data Sheet
I-BET151 dihydrochloride
Catalog No. A40356
I-BET151 dihydrochloride is a selective inhibitor of the bromodomain and extraterminal (BET) family, targeting BRD2, BRD3, and BRD4 with pIC50 values of 6.1, 6.3, and 6.6, respectively. This compound effectively disrupts the interaction between BET proteins and acetylated lysines, leading to a reduction in transcriptional activity of key oncogenes. I-BET151 dihydrochloride is primarily utilized in cancer research and studies related to inflammatory diseases, making it a valuable tool for elucidating the role of BET proteins in various biological processes.
Chemical Information
| Catalog Num | A40356 |
|---|---|
| M. Wt | 488.37 |
| Formula | C23H23Cl2N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1883545-47-8 |
| Synonyms | GSK1210151A dihydrochloride |
| SMILES | [H]Cl.[H]Cl.C[C@@H](N1C(C(C=C(OC)C(C2=C(C)ON=C2C)=C3)=C3N=C4)=C4NC1=O)C5=CC=CC=N5 |
Biological Activity
| Description | I-BET151 dihydrochloride is a selective inhibitor of the bromodomain and extraterminal (BET) family, targeting BRD2, BRD3, and BRD4 with pIC50 values of 6.1, 6.3, and 6.6, respectively. This compound effectively disrupts the interaction between BET proteins and acetylated lysines, leading to a reduction in transcriptional activity of key oncogenes. I-BET151 dihydrochloride is primarily utilized in cancer research and studies related to inflammatory diseases, making it a valuable tool for elucidating the role of BET proteins in various biological processes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
