Product Data Sheet
NC-III-49-1
Catalog No. A40407
NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with high affinity for BRD4 and BRDT family proteins, exhibiting Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2, and 5.5 nM for BRDT-2, among others. This compound demonstrates notable antiproliferative activity and effectively reduces c-Myc expression. NC-III-49-1 is valuable for research in cancer biology and therapeutic studies targeting BET-related pathways.
Chemical Information
| Catalog Num | A40407 |
|---|---|
| M. Wt | 875.02 |
| Formula | C44H50N4O11S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3031654-46-0 |
| Synonyms | |
| SMILES | CCS(=O)(NC1=CC=C(C(C(C2=C3C=CC=C2)=CN(C3=O)C)=C1)OCCOCCOCCOCCOC4=CC=C(C=C4C(C5=C6C=CC=C5)=CN(C6=O)C)NS(CC)(=O)=O)=O |
Biological Activity
| Description | NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with high affinity for BRD4 and BRDT family proteins, exhibiting Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2, and 5.5 nM for BRDT-2, among others. This compound demonstrates notable antiproliferative activity and effectively reduces c-Myc expression. NC-III-49-1 is valuable for research in cancer biology and therapeutic studies targeting BET-related pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
