Product Data Sheet
BRD4 Inhibitor-40
Catalog No. A40438
BRD4 Inhibitor-40 primarily targets the bromodomain protein BRD4, inhibiting its binding domains BRD4-BD1 and BRD4-BD2 with IC50 values of 16.1 nM and 142.18 nM, respectively. This compound effectively modulates the expression of c-Myc and p21, resulting in G1 phase cell cycle arrest. Additionally, BRD4 Inhibitor-40 has demonstrated efficacy in inhibiting Pkd1-null renal cystic epithelial cells and blocking renal cyst formation in both Madin-Darby canine kidney and embryonic kidney vesicle models, thus showcasing its potential in renal research applications.
Chemical Information
| Catalog Num | A40438 |
|---|---|
| M. Wt | 484.60 |
| Formula | C27H32N8O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2994635-04-8 |
| Synonyms | |
| SMILES | CC(N1C2=CC(NC3=NC(CC)=CC(NC4=NN(C)C5=CC=CC=C45)=N3)=CC=C2N(C([C@H]1C)=O)C)C |
Biological Activity
| Description | BRD4 Inhibitor-40 primarily targets the bromodomain protein BRD4, inhibiting its binding domains BRD4-BD1 and BRD4-BD2 with IC50 values of 16.1 nM and 142.18 nM, respectively. This compound effectively modulates the expression of c-Myc and p21, resulting in G1 phase cell cycle arrest. Additionally, BRD4 Inhibitor-40 has demonstrated efficacy in inhibiting Pkd1-null renal cystic epithelial cells and blocking renal cyst formation in both Madin-Darby canine kidney and embryonic kidney vesicle models, thus showcasing its potential in renal research applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
