Product Data Sheet
PROTAC SMARCA2 degrader-19
Catalog No. A40452
PROTAC SMARCA2 degrader-19 is a targeted protein degradative compound designed to degrade the SMARCA2 protein via a PROTAC mechanism. It demonstrates significant efficacy in A549 and MV411 cell lines with a DC50 of less than 100 nM. Additionally, this compound exhibits a reduced degradation effect on SMARCA4 in MV411 cells, with a DC50 exceeding 1000 nM. This specificity makes PROTAC SMARCA2 degrader-19 a valuable tool for studying the biological roles of SMARCA2 and its potential implications in cancer research.
Chemical Information
| Catalog Num | A40452 |
|---|---|
| M. Wt | 911.12 |
| Formula | C50H58N10O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2567913-00-0 |
| Synonyms | |
| SMILES | OC1=C(C=CC=C1)C2=NN=C3NC=C(C4CCN(C5=NC=C([C@@H]6CC[C@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(C)N=CS9)C=C8)=O)=O)=O)C=N5)CC4)C3=C2 |
Biological Activity
| Description | PROTAC SMARCA2 degrader-19 is a targeted protein degradative compound designed to degrade the SMARCA2 protein via a PROTAC mechanism. It demonstrates significant efficacy in A549 and MV411 cell lines with a DC50 of less than 100 nM. Additionally, this compound exhibits a reduced degradation effect on SMARCA4 in MV411 cells, with a DC50 exceeding 1000 nM. This specificity makes PROTAC SMARCA2 degrader-19 a valuable tool for studying the biological roles of SMARCA2 and its potential implications in cancer research. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
