Product Data Sheet
PROTAC SMARCA2 degrader-7
Catalog No. A40467
PROTAC SMARCA2 degrader-7 (Compound I-428) selectively targets and degrades the SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A, specifically SMARCA2. It has demonstrated effective degradation of both SMARCA2 and SMARCA4 in the MV411 cell line, with DC50 values of less than 100 nM and between 100-500 nM, respectively. This compound serves as a valuable tool for studying chromatin remodeling and its implications in cancer biology and therapeutic development.
Chemical Information
| Catalog Num | A40467 |
|---|---|
| M. Wt | 915.16 |
| Formula | C50H62N10O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2568277-71-2 |
| Synonyms | |
| SMILES | O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(C(CC4)(CC5)CCC45CN6CCC(N7C=C(C8=C(N)N=NC(C9=C(C=CC=C9)O)=C8)C=N7)CC6)=O |
Biological Activity
| Description | PROTAC SMARCA2 degrader-7 (Compound I-428) selectively targets and degrades the SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A, specifically SMARCA2. It has demonstrated effective degradation of both SMARCA2 and SMARCA4 in the MV411 cell line, with DC50 values of less than 100 nM and between 100-500 nM, respectively. This compound serves as a valuable tool for studying chromatin remodeling and its implications in cancer biology and therapeutic development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
