Product Data Sheet
PROTAC SMARCA2/4-degrader-20
Catalog No. A40482
PROTAC SMARCA2/4-degrader-20 is a novel PROTAC degrader targeting the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. This compound effectively induces degradation of SMARCA2 in A549 and MV411 cell lines with a DC50 of less than 100 nM, while degrading SMARCA4 in MV411 cells with a DC50 range of 100-500 nM. It serves as a valuable tool for studying the functional roles of SWI/SNF complex components in various biological processes and disease states.
Chemical Information
| Catalog Num | A40482 |
|---|---|
| M. Wt | 998.13 |
| Formula | C50H58F3N11O6S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2568277-38-1 |
| Synonyms | |
| SMILES | NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C([C@@H]6CC[C@H](CC6)C(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=C(C=C(C9=C(N=CS9)C)C=C8)OC(F)(F)F)=O)=O)=O)C=N5)C(CC4)C3 |
Biological Activity
| Description | PROTAC SMARCA2/4-degrader-20 is a novel PROTAC degrader targeting the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. This compound effectively induces degradation of SMARCA2 in A549 and MV411 cell lines with a DC50 of less than 100 nM, while degrading SMARCA4 in MV411 cells with a DC50 range of 100-500 nM. It serves as a valuable tool for studying the functional roles of SWI/SNF complex components in various biological processes and disease states. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
