Product Data Sheet
JV8
Catalog No. A40487
JV8 is a potent BRD4 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of the BRD4 protein, leading to induced apoptosis. This compound exhibits significant antitumor activity, demonstrated in a 4T1 orthotopic tumor model in mice. JV8 serves as a valuable tool for research in cancer therapeutics and the study of protein degradation pathways.
Chemical Information
| Catalog Num | A40487 |
|---|---|
| M. Wt | 1016.67 |
| Formula | C50H62ClN9O8S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2841716-61-6 |
| Synonyms | |
| SMILES | O=C(NCCOCCOCCOCC(N[C@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)=O)C[C@@H]4N=C(C5=CC=C(Cl)C=C5)C6=C(SC(C)=C6C)N7C4=NN=C7C |
Biological Activity
| Description | JV8 is a potent BRD4 PROTAC degrader that facilitates the ubiquitination and subsequent degradation of the BRD4 protein, leading to induced apoptosis. This compound exhibits significant antitumor activity, demonstrated in a 4T1 orthotopic tumor model in mice. JV8 serves as a valuable tool for research in cancer therapeutics and the study of protein degradation pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
