Product Data Sheet
BRD4 Inhibitor-28
Catalog No. A40509
BRD4 Inhibitor-28 is a selective inhibitor of the bromodomain protein BRD4, targeting the BRD4-BD1 and BRD4-BD2 domains with IC50 values of 15 nM and 55 nM, respectively. Additionally, it demonstrates inhibitory effects on BRD2-BD1, BRD3-BD1, and BRDT-BD1, with IC50 values of 19 nM, 25 nM, and 68 nM. This compound exhibits notable anti-melanoma activity, making it valuable for research in cancer therapeutics and epigenetic modulation.
Chemical Information
| Catalog Num | A40509 |
|---|---|
| M. Wt | 387.43 |
| Formula | C23H21N3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2468960-80-5 |
| Synonyms | |
| SMILES | O=C1N2CCOC3=C2C(N1CC4=CC=CC=C4)=CC(C5=CN(C(C(C)=C5)=O)C)=C3 |
Biological Activity
| Description | BRD4 Inhibitor-28 is a selective inhibitor of the bromodomain protein BRD4, targeting the BRD4-BD1 and BRD4-BD2 domains with IC50 values of 15 nM and 55 nM, respectively. Additionally, it demonstrates inhibitory effects on BRD2-BD1, BRD3-BD1, and BRDT-BD1, with IC50 values of 19 nM, 25 nM, and 68 nM. This compound exhibits notable anti-melanoma activity, making it valuable for research in cancer therapeutics and epigenetic modulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
