Product Data Sheet
SJ1461
Catalog No. A40512
SJ1461 is a potent BET inhibitor that selectively targets bromodomain-containing proteins BRD2 and BRD4. It demonstrates high affinity with IC50 values of 1.6 nM for BRD2 (BD1), 0.1 nM for BRD2 (BD2), 6.5 nM for BRD4 (BD1), and 0.2 nM for BRD4 (BD2). SJ1461 is utilized in research applications related to cancer, inflammation, and epigenetic regulation, making it a valuable tool for investigating the role of BET proteins in various biological processes.
Chemical Information
| Catalog Num | A40512 |
|---|---|
| M. Wt | 484.00 |
| Formula | C21H18ClN7OS2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2924546-70-1 |
| Synonyms | |
| SMILES | CC1=NN=C2[C@@H](N=C(C3=C(N12)SC(C)=C3C)C4=CC=C(C=C4)Cl)CC(NC5=NN=CS5)=O |
Biological Activity
| Description | SJ1461 is a potent BET inhibitor that selectively targets bromodomain-containing proteins BRD2 and BRD4. It demonstrates high affinity with IC50 values of 1.6 nM for BRD2 (BD1), 0.1 nM for BRD2 (BD2), 6.5 nM for BRD4 (BD1), and 0.2 nM for BRD4 (BD2). SJ1461 is utilized in research applications related to cancer, inflammation, and epigenetic regulation, making it a valuable tool for investigating the role of BET proteins in various biological processes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
