Product Data Sheet
XY153
Catalog No. A40543
XY153 is a BD2-selective BET inhibitor that primarily targets the bromodomain 2 (BD2) of the BRD4 protein. It exhibits potent binding affinity to BRD4 BD2, BRD3 BD2, and BRD2 BD2, with IC50 values of 0.79 nM, 5.31 nM, and 5.09 nM, respectively. XY153 demonstrates significant antiproliferative effects across various tumor cell lines and is applicable in research focused on acute myeloid leukemia (AML) and cancer therapeutics.
Chemical Information
| Catalog Num | A40543 |
|---|---|
| M. Wt | 555.64 |
| Formula | C33H34FN3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2933176-32-8 |
| Synonyms | |
| SMILES | CC1=CC(F)=CC(C)=C1OC2=C(C=C(C=C2)C(C)(O)C)C3=CN(C(C4=C3OC(C5=CN=C(N5)C6CCCC6)=C4)=O)C |
Biological Activity
| Description | XY153 is a BD2-selective BET inhibitor that primarily targets the bromodomain 2 (BD2) of the BRD4 protein. It exhibits potent binding affinity to BRD4 BD2, BRD3 BD2, and BRD2 BD2, with IC50 values of 0.79 nM, 5.31 nM, and 5.09 nM, respectively. XY153 demonstrates significant antiproliferative effects across various tumor cell lines and is applicable in research focused on acute myeloid leukemia (AML) and cancer therapeutics. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
