Product Data Sheet
SMARCA2-IN-4
Catalog No. A40559
SMARCA2-IN-4 is a selective inhibitor of the SWI/SNF chromatin remodeling complex, specifically targeting the bromodomains of SMARCA proteins. This compound demonstrates high binding affinity for PB1, SMARCA2B, and SMARCA4, with dissociation constants (Kd) of 124 nM, 262 nM, and 417 nM, respectively. SMARCA2-IN-4 is valuable for studies investigating the roles of chromatin remodeling in gene expression and cellular processes, offering potential insights into cancer biology and epigenetic regulation.
Chemical Information
| Catalog Num | A40559 |
|---|---|
| M. Wt | 330.81 |
| Formula | C17H19ClN4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1915012-19-9 |
| Synonyms | |
| SMILES | CN(CC1)CCN1/C=C2CCN(C\2=N3)C4=CC=CC(Cl)=C4C3=O |
Biological Activity
| Description | SMARCA2-IN-4 is a selective inhibitor of the SWI/SNF chromatin remodeling complex, specifically targeting the bromodomains of SMARCA proteins. This compound demonstrates high binding affinity for PB1, SMARCA2B, and SMARCA4, with dissociation constants (Kd) of 124 nM, 262 nM, and 417 nM, respectively. SMARCA2-IN-4 is valuable for studies investigating the roles of chromatin remodeling in gene expression and cellular processes, offering potential insights into cancer biology and epigenetic regulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
