Product Data Sheet
CZL-077
Catalog No. A40581
CZL-077 is a selective and potent inhibitor of the bromodomains of p300 and CBP, with IC50 values of 0.034 μM and 0.052 μM, respectively. It demonstrates high specificity for p300/CBP over BET proteins, making it a valuable tool in the study of epigenetic regulation. CZL-077 effectively inhibits the growth of multiple myeloma and prostate cancer cell lines, with IC50 values of 0.024 μM in OPM-2 and 5.6 μM in 22RV1 cells. Additionally, it exhibits significant antitumor activity in xenograft mouse models, supporting its potential use in cancer research.
Chemical Information
| Catalog Num | A40581 |
|---|---|
| M. Wt | 577.62 |
| Formula | C30H26F3N5O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3032444-06-4 |
| Synonyms | |
| SMILES | CC1=NC(CC2)=C(S1)C[C@@H]2N3C([C@H]4N(C5=CC=C(F)C(F)=C5)C([C@@H](F)C4)=O)=NC6=CC(C7=C(C)ON=C7C)=CC=C63 |
Biological Activity
| Description | CZL-077 is a selective and potent inhibitor of the bromodomains of p300 and CBP, with IC50 values of 0.034 μM and 0.052 μM, respectively. It demonstrates high specificity for p300/CBP over BET proteins, making it a valuable tool in the study of epigenetic regulation. CZL-077 effectively inhibits the growth of multiple myeloma and prostate cancer cell lines, with IC50 values of 0.024 μM in OPM-2 and 5.6 μM in 22RV1 cells. Additionally, it exhibits significant antitumor activity in xenograft mouse models, supporting its potential use in cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
