Product Data Sheet
BET-IN-27
Catalog No. A40606
BET-IN-27 is a potent inhibitor of bromodomain and extraterminal (BET) proteins, demonstrating IC50 values of 3.3 nM for BRD4-BD2, 3.4 nM for BRD4-BD1, 4.1 nM for BRD2-BD1, 20.4 nM for BRD3-BD1, and 42.0 nM for BRDT-BD1. This compound exhibits significant anti-proliferative effects, making it a valuable tool for research in cancer biology and therapeutic development targeting BET protein pathways. Its selective inhibition profile allows for further exploration of BET proteins in various disease models.
Chemical Information
| Catalog Num | A40606 |
|---|---|
| M. Wt | 425.50 |
| Formula | C21H23N5O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3054869-29-0 |
| Synonyms | |
| SMILES | CN(C(C1=C2C=CN1)=O)C=C2C3=NC4=C(SC(C(C)(C)O)=C4)C(N5CCOCC5)=N3 |
Biological Activity
| Description | BET-IN-27 is a potent inhibitor of bromodomain and extraterminal (BET) proteins, demonstrating IC50 values of 3.3 nM for BRD4-BD2, 3.4 nM for BRD4-BD1, 4.1 nM for BRD2-BD1, 20.4 nM for BRD3-BD1, and 42.0 nM for BRDT-BD1. This compound exhibits significant anti-proliferative effects, making it a valuable tool for research in cancer biology and therapeutic development targeting BET protein pathways. Its selective inhibition profile allows for further exploration of BET proteins in various disease models. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
