Product Data Sheet
AS601245 TFA
Catalog No. A40680
AS601245 TFA is a selective, ATP-competitive inhibitor of c-Jun NH2-terminal protein kinases (JNK), demonstrating IC50 values of 150 nM for hJNK1, 220 nM for hJNK2, and 70 nM for hJNK3. This compound exhibits significant selectivity, being 10- to 20-fold more selective for JNK over kinases such as c-src, CDK2, and c-Raf, and shows more than 50- to 100-fold selectivity against various Ser/Thr and Tyr-protein kinases. AS601245 TFA is suitable for applications involving neuroprotection and the study of cellular stress response pathways in research settings.
Chemical Information
| Catalog Num | A40680 |
|---|---|
| M. Wt | 600.49 |
| Formula | C24H18F6N6O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 345987-16-8 |
| Synonyms | |
| SMILES | N#CC(C1=CC=NC(NCCC2=CC=CN=C2)=N1)C3=NC4=CC=CC=C4S3.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O |
Biological Activity
| Description | AS601245 TFA is a selective, ATP-competitive inhibitor of c-Jun NH2-terminal protein kinases (JNK), demonstrating IC50 values of 150 nM for hJNK1, 220 nM for hJNK2, and 70 nM for hJNK3. This compound exhibits significant selectivity, being 10- to 20-fold more selective for JNK over kinases such as c-src, CDK2, and c-Raf, and shows more than 50- to 100-fold selectivity against various Ser/Thr and Tyr-protein kinases. AS601245 TFA is suitable for applications involving neuroprotection and the study of cellular stress response pathways in research settings. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
