Product Data Sheet
Locostatin
Catalog No. A40684
Locostatin is a potent inhibitor of Raf kinase inhibitor protein (RKIP), which disrupts its interactions with Raf-1 kinase and G protein-coupled receptor kinase 2. This compound demonstrates significant inhibition of cell proliferation and migration, making it a valuable tool for studying cellular signaling pathways. Additionally, Locostatin is useful for synthesizing chemical probes targeting PEBP proteins and has shown to exacerbate thioacetamide-induced acute liver failure in murine models, thereby providing insights into liver pathology.
Chemical Information
| Catalog Num | A40684 |
|---|---|
| M. Wt | 245.27 |
| Formula | C14H15NO3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 90719-30-5 |
| Synonyms | UIC-1005 |
| SMILES | O=C1OC[C@H](CC2=CC=CC=C2)N1C(/C=C/C)=O |
Biological Activity
| Description | Locostatin is a potent inhibitor of Raf kinase inhibitor protein (RKIP), which disrupts its interactions with Raf-1 kinase and G protein-coupled receptor kinase 2. This compound demonstrates significant inhibition of cell proliferation and migration, making it a valuable tool for studying cellular signaling pathways. Additionally, Locostatin is useful for synthesizing chemical probes targeting PEBP proteins and has shown to exacerbate thioacetamide-induced acute liver failure in murine models, thereby providing insights into liver pathology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
