Product Data Sheet
Claturafenib
Catalog No. A40685
Claturafenib is a potent, orally active pan-mutant BRAF inhibitor. It effectively inhibits phosphorylated ERK (pERK) in cells, demonstrating an IC50 value of 1.6 nM in HT29 cell lines. Claturafenib exhibits significant antitumor activity against non-small cell lung cancer (NSCLC) harboring the BRAFG469A mutation and melanoma with the BRAFK601E mutation, making it a valuable tool for cancer research focused on BRAF mutant pathways.
Chemical Information
| Catalog Num | A40685 |
|---|---|
| M. Wt | 490.31 |
| Formula | C18H15Cl2F2N5O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2754408-94-9 |
| Synonyms | PF-07799933; ARRY-440 |
| SMILES | O=C1C2=C(C=CC(NC3=C(Cl)C(NS(=O)(N4CC(C4)F)=O)=CC=C3F)=C2Cl)N=CN1C |
Biological Activity
| Description | Claturafenib is a potent, orally active pan-mutant BRAF inhibitor. It effectively inhibits phosphorylated ERK (pERK) in cells, demonstrating an IC50 value of 1.6 nM in HT29 cell lines. Claturafenib exhibits significant antitumor activity against non-small cell lung cancer (NSCLC) harboring the BRAFG469A mutation and melanoma with the BRAFK601E mutation, making it a valuable tool for cancer research focused on BRAF mutant pathways. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
