Product Data Sheet
B-Raf IN 11
Catalog No. A40688
B-Raf IN 11 is a selective inhibitor of the B-RafV600E mutant kinase, demonstrating an IC50 of 76 nM, and exhibits an IC50 of 238 nM against wild-type B-Raf kinase. This compound effectively inhibits the kinase activities of both B-RafV600E mutant and wild-type B-Raf, making it a valuable tool for investigating pathways related to colorectal cancer. Its application in research provides insight into therapeutic strategies targeting B-Raf mutations in cancer treatment.
Chemical Information
| Catalog Num | A40688 |
|---|---|
| M. Wt | 458.28 |
| Formula | C17H14BrF2N3O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 918504-27-5 |
| Synonyms | |
| SMILES | FC1=C(C(C2=CNC3=NC=C(Br)C=C32)=O)C(F)=C(NS(=O)(CCC)=O)C=C1 |
Biological Activity
| Description | B-Raf IN 11 is a selective inhibitor of the B-RafV600E mutant kinase, demonstrating an IC50 of 76 nM, and exhibits an IC50 of 238 nM against wild-type B-Raf kinase. This compound effectively inhibits the kinase activities of both B-RafV600E mutant and wild-type B-Raf, making it a valuable tool for investigating pathways related to colorectal cancer. Its application in research provides insight into therapeutic strategies targeting B-Raf mutations in cancer treatment. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
