Product Data Sheet
Braftide
Catalog No. A40691
Braftide is an allosteric inhibitor of BRAF kinase that targets the dimer interface, effectively preventing the formation of BRAF dimers. It exhibits inhibitory activity against both wild-type BRAF and the oncogenic variant BRAFG469A, with IC50 values of 364 nM and 172 nM, respectively. By inhibiting the MAPK signaling pathway, Braftide demonstrates the ability to suppress the proliferation of KRAS mutant tumor cells, with EC50 values of 7.1 µM and 6.6 µM for HCT116 and HCT-15 cell lines, respectively. This compound is applicable in various cancer research studies.
Chemical Information
| Catalog Num | A40691 |
|---|---|
| M. Wt | 1243.52 |
| Formula | C57H94N16O13S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2411851-64-2 |
| Synonyms | |
| SMILES | [C@@H](CC1=CN=CN1)(NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)CCCNC(=N)N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCSC)C(O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)[C@H](CC)C)=O)CC(N)=O)=O)[C@H](C)C)=O |
Biological Activity
| Description | Braftide is an allosteric inhibitor of BRAF kinase that targets the dimer interface, effectively preventing the formation of BRAF dimers. It exhibits inhibitory activity against both wild-type BRAF and the oncogenic variant BRAFG469A, with IC50 values of 364 nM and 172 nM, respectively. By inhibiting the MAPK signaling pathway, Braftide demonstrates the ability to suppress the proliferation of KRAS mutant tumor cells, with EC50 values of 7.1 µM and 6.6 µM for HCT116 and HCT-15 cell lines, respectively. This compound is applicable in various cancer research studies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
