Product Data Sheet
GNE-9815
Catalog No. A40695
GNE-9815 is a highly selective pan-RAF inhibitor that targets both CRAF and BRAF with Ki values of 0.062 nM and 0.19 nM, respectively. It demonstrates good oral bioavailability and, when used in conjunction with MEK inhibitors such as Cobimetinib, leads to synergistic modulation of the MAPK pathway. GNE-9815 is particularly useful in research focused on KRAS mutant cancers, facilitating the exploration of therapeutic strategies in this context.
Chemical Information
| Catalog Num | A40695 |
|---|---|
| M. Wt | 455.48 |
| Formula | C26H22FN5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2729996-45-4 |
| Synonyms | |
| SMILES | N#CC(C)(C)C1=CC(C(NC2=C(F)C=C(C)C(C3=CN=C4C(C=NN(C)C4=O)=C3)=C2)=O)=CC=C1 |
Biological Activity
| Description | GNE-9815 is a highly selective pan-RAF inhibitor that targets both CRAF and BRAF with Ki values of 0.062 nM and 0.19 nM, respectively. It demonstrates good oral bioavailability and, when used in conjunction with MEK inhibitors such as Cobimetinib, leads to synergistic modulation of the MAPK pathway. GNE-9815 is particularly useful in research focused on KRAS mutant cancers, facilitating the exploration of therapeutic strategies in this context. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
