Product Data Sheet
SHR902275
Catalog No. A40697
SHR902275 is a selective and potent b/cRAF inhibitor, specifically designed to target RAS mutant cancers. It demonstrates impressive inhibitory activity with IC50 values of 1.6 nM for cRAF, 10 nM for bRAFwt, and 5.7 nM for the bRAFV600E mutation. In cellular assays, SHR902275 effectively inhibits growth with GI50 values of 1.5 nM and 0.17 nM for H358, as well as 0.4 nM and 0.32 nM for A375 and Calu6, and SK-MEL2 cells, respectively. This compound holds potential for research applications focused on targeted cancer therapies and understanding RAF signaling pathways.
Chemical Information
| Catalog Num | A40697 |
|---|---|
| M. Wt | 512.48 |
| Formula | C26H23F3N4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2695506-82-0 |
| Synonyms | |
| SMILES | O=C(C1=NN=CC(C(F)(F)F)=C1)NC2=CC=C(C)C(C3=CC4=C(NC(CC5(CCOCC5)O4)=O)C=C3)=C2 |
Biological Activity
| Description | SHR902275 is a selective and potent b/cRAF inhibitor, specifically designed to target RAS mutant cancers. It demonstrates impressive inhibitory activity with IC50 values of 1.6 nM for cRAF, 10 nM for bRAFwt, and 5.7 nM for the bRAFV600E mutation. In cellular assays, SHR902275 effectively inhibits growth with GI50 values of 1.5 nM and 0.17 nM for H358, as well as 0.4 nM and 0.32 nM for A375 and Calu6, and SK-MEL2 cells, respectively. This compound holds potential for research applications focused on targeted cancer therapies and understanding RAF signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
