Product Data Sheet
Belvarafenib TFA
Catalog No. A40699
Belvarafenib TFA is a potent pan-RAF inhibitor that targets the rapidly accelerated fibrosarcoma (RAF) family of kinases. It demonstrates impressive inhibitory activity, with IC50 values of 56 nM for B-RAF, 7 nM for B-RAFV600E, and 5 nM for C-RAF. This compound is valuable for research focusing on cancer therapeutics, particularly for the treatment of tumors driven by aberrant RAF signaling pathways.
Chemical Information
| Catalog Num | A40699 |
|---|---|
| M. Wt | 592.95 |
| Formula | C25H17ClF4N6O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2443966-84-3 |
| Synonyms | HM95573 TFA; GDC-5573 TFA; RG6185 TFA |
| SMILES | O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C.OC(C(F)(F)F)=O |
Biological Activity
| Description | Belvarafenib TFA is a potent pan-RAF inhibitor that targets the rapidly accelerated fibrosarcoma (RAF) family of kinases. It demonstrates impressive inhibitory activity, with IC50 values of 56 nM for B-RAF, 7 nM for B-RAFV600E, and 5 nM for C-RAF. This compound is valuable for research focusing on cancer therapeutics, particularly for the treatment of tumors driven by aberrant RAF signaling pathways. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
