Product Data Sheet
Avutometinib potassium
Catalog No. A40710
Avutometinib potassium is a potent RAF/MEK inhibitor that effectively prevents MEK phosphorylation by ARAF, BRAF, and CRAF through the formation of dominant negative RAF-MEK complexes. This compound exhibits significant anti-proliferative activity across various tumor cell lines, particularly those with KRAS mutations, including pancreatic ductal adenocarcinoma (PDAC) cell lines. In vivo studies demonstrate that Avutometinib potassium inhibits tumor growth and enhances survival in mouse models of KRAS and p53 mutant pancreatic cancer. It holds potential for research in low-grade serous ovarian carcinoma and other oncogenic conditions involving the RAF/MEK pathway.
Chemical Information
| Catalog Num | A40710 |
|---|---|
| M. Wt | 510.56 |
| Formula | C21H18FKN5O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 946128-90-1 |
| Synonyms | Ro 5126766 potassium; CH5126766 potassium |
| SMILES | O=S(NC)(NC1=NC=CC(CC2=C(C)C3=CC=C(OC4=NC=CC=N4)C=C3OC2=O)=C1F)=O.[K] |
Biological Activity
| Description | Avutometinib potassium is a potent RAF/MEK inhibitor that effectively prevents MEK phosphorylation by ARAF, BRAF, and CRAF through the formation of dominant negative RAF-MEK complexes. This compound exhibits significant anti-proliferative activity across various tumor cell lines, particularly those with KRAS mutations, including pancreatic ductal adenocarcinoma (PDAC) cell lines. In vivo studies demonstrate that Avutometinib potassium inhibits tumor growth and enhances survival in mouse models of KRAS and p53 mutant pancreatic cancer. It holds potential for research in low-grade serous ovarian carcinoma and other oncogenic conditions involving the RAF/MEK pathway. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
