Product Data Sheet
LSN3074753
Catalog No. A40711
LSN3074753 is a pan-RAF inhibitor targeting RAF monomers and dimers, particularly effective against tumor cells with activated MAPK pathways driven by BRAF or KRAS mutations. This reagent exhibits significant antitumor activity, making it a valuable tool for research applications involving colorectal cancer models. In combination with Cetuximab, LSN3074753 produces additive and synergistic effects, highlighting its potential for therapeutic strategies in tumors with specific genetic alterations such as KRAS or BRAF mutations.
Chemical Information
| Catalog Num | A40711 |
|---|---|
| M. Wt | 439.53 |
| Formula | C24H30FN5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1455031-68-1 |
| Synonyms | |
| SMILES | O=C(NC[C@@H](O)C(C)(C)C)NC1=CC(C2=CC3=CN=C(NC)C=C3N=C2C)=C(C)C=C1F |
Biological Activity
| Description | LSN3074753 is a pan-RAF inhibitor targeting RAF monomers and dimers, particularly effective against tumor cells with activated MAPK pathways driven by BRAF or KRAS mutations. This reagent exhibits significant antitumor activity, making it a valuable tool for research applications involving colorectal cancer models. In combination with Cetuximab, LSN3074753 produces additive and synergistic effects, highlighting its potential for therapeutic strategies in tumors with specific genetic alterations such as KRAS or BRAF mutations. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
