Product Data Sheet
CST905
Catalog No. A40714
CST905 is a highly effective PROTAC degrader specifically targeting the BRAF-V600E mutation, demonstrating a DC50 value of 18 nM. This compound facilitates the selective degradation of the BRAF-V600E protein, making it a valuable tool for cancer research aimed at understanding and addressing mutant BRAF-driven tumors. Its ability to modulate protein levels through targeted ubiquitination offers significant potential for therapeutic applications in oncology.
Chemical Information
| Catalog Num | A40714 |
|---|---|
| M. Wt | 1025.20 |
| Formula | C51H58F2N10O7S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3094183-98-6 |
| Synonyms | |
| SMILES | O=C([C@H]1N(C([C@@H](NC(CN2CCN(C3=CC=C(C4=CN=C(NC=C5C(C6=C(F)C=CC(NS(=O)(N(CC)C)=O)=C6F)=O)C5=C4)C=C3)CC2)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC7=CC=C(C8=C(C)N=CS8)C=C7 |
Biological Activity
| Description | CST905 is a highly effective PROTAC degrader specifically targeting the BRAF-V600E mutation, demonstrating a DC50 value of 18 nM. This compound facilitates the selective degradation of the BRAF-V600E protein, making it a valuable tool for cancer research aimed at understanding and addressing mutant BRAF-driven tumors. Its ability to modulate protein levels through targeted ubiquitination offers significant potential for therapeutic applications in oncology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
