Product Data Sheet
pan-Raf/RTK inhibitor 1
Catalog No. A40717
Pan-Raf/RTK inhibitor 1 (compound I-16) is a highly selective pan-Raf inhibitor that targets the Raf kinases with IC50 values of 3.49 nM for BRafV600E, 8.86 nM for ARaf, 5.78 nM for BRafWT, and 1.65 nM for CRaf. This compound exhibits significant antiproliferative effects across a range of cancer cell lines, making it a valuable tool for cancer research. Its ability to inhibit multiple Raf isoforms facilitates studies investigating the role of the Raf signaling pathway in tumorigenesis and therapeutic resistance.
Chemical Information
| Catalog Num | A40717 |
|---|---|
| M. Wt | 579.57 |
| Formula | C29H28F3N7O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1980821-53-1 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(C)C(NC(C2(CC2)C3=NC=NC4=C3NC=N4)=O)=C1)NC5=CC=C(CN6CCOCC6)C(C(F)(F)F)=C5 |
Biological Activity
| Description | Pan-Raf/RTK inhibitor 1 (compound I-16) is a highly selective pan-Raf inhibitor that targets the Raf kinases with IC50 values of 3.49 nM for BRafV600E, 8.86 nM for ARaf, 5.78 nM for BRafWT, and 1.65 nM for CRaf. This compound exhibits significant antiproliferative effects across a range of cancer cell lines, making it a valuable tool for cancer research. Its ability to inhibit multiple Raf isoforms facilitates studies investigating the role of the Raf signaling pathway in tumorigenesis and therapeutic resistance. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
