Product Data Sheet
RAF-IN-1
Catalog No. A40726
RAF-IN-1 is a potent inhibitor of b/cRAF, demonstrating IC50 values of 3.8 nM for cRAF, 36 nM for bRAF wild-type, and 29.4 nM for the bRAFV600E mutant. This compound effectively inhibits cell growth in cancer cell lines harboring the bRAFV600E mutation, with GI50 values of 3.4 nM in H358 and 2.9 nM in A375 cells. RAF-IN-1 is valuable for research in cancer biology, particularly in studies targeting the RAS-RAF-MEK-ERK signaling pathway.
Chemical Information
| Catalog Num | A40726 |
|---|---|
| M. Wt | 497.47 |
| Formula | C26H22F3N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2695505-82-7 |
| Synonyms | |
| SMILES | O=C(C1=CC(C(F)(F)F)=NC=C1)NC2=CC=C(C)C(C3=CC4=C(C(NC5(CCOCC5)O4)=O)C=C3)=C2 |
Biological Activity
| Description | RAF-IN-1 is a potent inhibitor of b/cRAF, demonstrating IC50 values of 3.8 nM for cRAF, 36 nM for bRAF wild-type, and 29.4 nM for the bRAFV600E mutant. This compound effectively inhibits cell growth in cancer cell lines harboring the bRAFV600E mutation, with GI50 values of 3.4 nM in H358 and 2.9 nM in A375 cells. RAF-IN-1 is valuable for research in cancer biology, particularly in studies targeting the RAS-RAF-MEK-ERK signaling pathway. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
