Product Data Sheet
B-Raf IN 8
Catalog No. A40729
B-Raf IN 8 is a potent inhibitor of the B-Raf kinase, exhibiting an IC50 of 70.65 nM. This compound demonstrates significant antitumor activity across various cancer cell lines, including hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland cancer (MCF-7), and human prostate cancer (PC-3), with IC50 values of 9.78 µM, 13.78 µM, 18.52 µM, and 29.85 µM, respectively. B-Raf IN 8 is a valuable tool for research into targeted cancer therapies and the mechanistic pathways associated with B-Raf signaling.
Chemical Information
| Catalog Num | A40729 |
|---|---|
| M. Wt | 307.35 |
| Formula | C18H17N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1215313-19-1 |
| Synonyms | |
| SMILES | O=C1CCC(C2=CC=C(/N=C/C3=CC=C(OC)C=C3)C=C2)=NN1 |
Biological Activity
| Description | B-Raf IN 8 is a potent inhibitor of the B-Raf kinase, exhibiting an IC50 of 70.65 nM. This compound demonstrates significant antitumor activity across various cancer cell lines, including hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland cancer (MCF-7), and human prostate cancer (PC-3), with IC50 values of 9.78 µM, 13.78 µM, 18.52 µM, and 29.85 µM, respectively. B-Raf IN 8 is a valuable tool for research into targeted cancer therapies and the mechanistic pathways associated with B-Raf signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
