Product Data Sheet
Everafenib
Catalog No. A40730
Everafenib is a highly selective BRAF inhibitor that effectively penetrates the blood-brain barrier (BBB) and inhibits MAPK signaling pathways. It demonstrates potent activity against various V600E BRAF melanoma cell lines, with IC50 values ranging from 2 to 10 nM, showcasing superior potency compared to other BRAF inhibitors. In vitro and in vivo studies indicate its efficacy in treating metastatic melanoma, including significant effects observed in an intracranial mouse model. This makes Everafenib a valuable tool for cancer research and therapeutic developments targeting BRAF mutations.
Chemical Information
| Catalog Num | A40730 |
|---|---|
| M. Wt | 484.01 |
| Formula | C20H23ClFN5O2S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2923700-82-5 |
| Synonyms | |
| SMILES | CC(C1=NC(C2=C(C(NS(CCC)(=O)=O)=CC(Cl)=C2)F)=C(C3=CC=NC(N)=N3)S1)(C)C |
Biological Activity
| Description | Everafenib is a highly selective BRAF inhibitor that effectively penetrates the blood-brain barrier (BBB) and inhibits MAPK signaling pathways. It demonstrates potent activity against various V600E BRAF melanoma cell lines, with IC50 values ranging from 2 to 10 nM, showcasing superior potency compared to other BRAF inhibitors. In vitro and in vivo studies indicate its efficacy in treating metastatic melanoma, including significant effects observed in an intracranial mouse model. This makes Everafenib a valuable tool for cancer research and therapeutic developments targeting BRAF mutations. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
