Product Data Sheet
K-14585
Catalog No. A40837
K-14585 is a peptide that acts as a competitive antagonist of protease-activated receptor 2 (PAR2). It effectively inhibits PAR2-mediated interleukin-8 (IL-8) production, as well as phosphorylation of NF-κB and p38 MAPK signaling pathways. Additionally, K-14585 significantly reduces calcium mobilization induced by the PAR2 agonist SLIGKV in primary human keratinocytes, making it a valuable tool for studying PAR2-related biological processes and inflammatory responses.
Chemical Information
| Catalog Num | A40837 |
|---|---|
| M. Wt | 915.95 |
| Formula | C51H56Cl2N8O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 880546-17-8 |
| Synonyms | |
| SMILES | ClC(C=CC=C1Cl)=C1CN2C(C(C(CN3CCCC3)=C2)=C4)=CC=C4NC(NCC(N[C@@H](CCCCN)C(N[C@@H](CC5=CC=CC=C5)C(NC(C6=CC=CC=C6)C7=CC=CC=C7)=O)=O)=O)=O |
Biological Activity
| Description | K-14585 is a peptide that acts as a competitive antagonist of protease-activated receptor 2 (PAR2). It effectively inhibits PAR2-mediated interleukin-8 (IL-8) production, as well as phosphorylation of NF-κB and p38 MAPK signaling pathways. Additionally, K-14585 significantly reduces calcium mobilization induced by the PAR2 agonist SLIGKV in primary human keratinocytes, making it a valuable tool for studying PAR2-related biological processes and inflammatory responses. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
