Product Data Sheet
NJK14047
Catalog No. A40863
NJK14047 is a selective inhibitor of p38 MAPK, a key signaling pathway involved in inflammatory responses. This compound effectively inhibits the differentiation of naive T-cells into Th1 and Th17 cells, thus modulating immune responses. NJK14047 has demonstrated therapeutic potential in preclinical models, ameliorating collagen-induced rheumatoid arthritis and imiquimod-induced psoriasis in mice, making it a valuable tool for research into inflammatory diseases and immune regulation.
Chemical Information
| Catalog Num | A40863 |
|---|---|
| M. Wt | 445.51 |
| Formula | C27H27NO5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1800576-41-3 |
| Synonyms | |
| SMILES | O=C(C1=CC(C2=CC=C(C(C3=CC=C(OCC(O)CO)C=C3)=O)C=C2)=C(C)C=C1)NC4CC4 |
Biological Activity
| Description | NJK14047 is a selective inhibitor of p38 MAPK, a key signaling pathway involved in inflammatory responses. This compound effectively inhibits the differentiation of naive T-cells into Th1 and Th17 cells, thus modulating immune responses. NJK14047 has demonstrated therapeutic potential in preclinical models, ameliorating collagen-induced rheumatoid arthritis and imiquimod-induced psoriasis in mice, making it a valuable tool for research into inflammatory diseases and immune regulation. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
