Product Data Sheet
p38-α MAPK-IN-9
Catalog No. A40871
p38-α MAPK-IN-9 is a highly potent inhibitor of the p38-α mitogen-activated protein kinase (MAPK), exhibiting a Ki value of 0.057 nM. This compound effectively inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNFα) production in human peripheral blood mononuclear cells (hPBMCs), with an IC50 of 18 nM. p38-α MAPK-IN-9 is valuable for research applications focused on inflammatory signaling pathways and the study of cytokine modulation.
Chemical Information
| Catalog Num | A40871 |
|---|---|
| M. Wt | 392.41 |
| Formula | C19H20N8O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 868272-50-8 |
| Synonyms | |
| SMILES | N#CC1=C(NC(C)C)N=C(N)N=C1NC2=CC(C(NC3=NOC=C3)=O)=CC=C2C |
Biological Activity
| Description | p38-α MAPK-IN-9 is a highly potent inhibitor of the p38-α mitogen-activated protein kinase (MAPK), exhibiting a Ki value of 0.057 nM. This compound effectively inhibits lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNFα) production in human peripheral blood mononuclear cells (hPBMCs), with an IC50 of 18 nM. p38-α MAPK-IN-9 is valuable for research applications focused on inflammatory signaling pathways and the study of cytokine modulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
