Product Data Sheet
LRRK2-IN-12
Catalog No. A40963
LRRK2-IN-12 is a potent inhibitor of LRRK2, effectively targeting G2019S (IC50=0.45 nM) and wild-type LRRK2 (IC50=1.1 nM), with a similar affinity for the wild-type enzyme in the presence of ADP (IC50=0.46 nM). This compound is valuable for research into neurodegenerative diseases, particularly in investigating the role of LRRK2 in Alzheimer's Disease. Its high specificity and low nanomolar activity make it an essential tool for exploring LRRK2-related pathways and therapeutic interventions.
Chemical Information
| Catalog Num | A40963 |
|---|---|
| M. Wt | 412.83 |
| Formula | C18H17ClN8O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3032733-05-1 |
| Synonyms | |
| SMILES | CC1=C(NC2=NC3=C4C=N2)C(OCCCN3N=C4Cl)=NN1C5=CC=CN=C5OC |
Biological Activity
| Description | LRRK2-IN-12 is a potent inhibitor of LRRK2, effectively targeting G2019S (IC50=0.45 nM) and wild-type LRRK2 (IC50=1.1 nM), with a similar affinity for the wild-type enzyme in the presence of ADP (IC50=0.46 nM). This compound is valuable for research into neurodegenerative diseases, particularly in investigating the role of LRRK2 in Alzheimer's Disease. Its high specificity and low nanomolar activity make it an essential tool for exploring LRRK2-related pathways and therapeutic interventions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
