Product Data Sheet

Glucocorticoid receptor agonist-2

Catalog No. A41019

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Glucocorticoid receptor agonist-2 is a potent agonist of the glucocorticoid receptor (GR) with an IC50 value of 6.6 nM. This compound is instrumental in synthesizing anti-inflammatory antibody-drug conjugates (ADCs), making it valuable for research in inflammation and immune response modulation. Its effectiveness as an active reference in studies related to GR-targeted therapies supports its applicability in therapeutic development.
Chemical Information
Catalog NumA41019
M. Wt607.64
FormulaC34H35F2NO7
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.2166378-92-1
Synonyms
SMILES[H][C@]1(C[C@]2(O[C@H](O[C@]23C(CO)=O)C4=CC=C(OC5=CC(N)=CC=C5)C=C4)[H])[C@@]6(C[C@@H](C7=CC(C=C[C@@]7([C@](F)6[C@@H](O)C[C@@]13C)C)=O)F)[H]
Biological Activity
DescriptionGlucocorticoid receptor agonist-2 is a potent agonist of the glucocorticoid receptor (GR) with an IC50 value of 6.6 nM. This compound is instrumental in synthesizing anti-inflammatory antibody-drug conjugates (ADCs), making it valuable for research in inflammation and immune response modulation. Its effectiveness as an active reference in studies related to GR-targeted therapies supports its applicability in therapeutic development.
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