Product Data Sheet
Duostatin 5
Catalog No. A41024
Duostatin 5 is an ADC cytotoxin that serves as a synthetic building block for antibody-drug conjugates (ADCs). It is derived from MMAF and allows for efficient conjugation to antibodies targeting 5T4 through a disubstituted C-Lock linker, enabling stable and straightforward synthesis. Duostatin 5 features an azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN groups. This reagent is valuable for researchers developing targeted therapies in cancer treatment.
Chemical Information
| Catalog Num | A41024 |
|---|---|
| M. Wt | 772.03 |
| Formula | C40H69N9O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2124210-34-8 |
| Synonyms | |
| SMILES | NC(C=C1)=CC=C1C[C@@H](CN=[N+]=[N-])NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)=O)OC)=O |
Biological Activity
| Description | Duostatin 5 is an ADC cytotoxin that serves as a synthetic building block for antibody-drug conjugates (ADCs). It is derived from MMAF and allows for efficient conjugation to antibodies targeting 5T4 through a disubstituted C-Lock linker, enabling stable and straightforward synthesis. Duostatin 5 features an azide functional group, facilitating copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN groups. This reagent is valuable for researchers developing targeted therapies in cancer treatment. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
