Product Data Sheet
DC0-NH2
Catalog No. A41035
DC0-NH2 is an effector moiety targeting antibody-drug conjugates (ADCs) with enhanced stability compared to its analog DC1. This compound exhibits remarkable cytotoxicity, demonstrating approximately 1000-fold greater potency than traditional anticancer agents like Doxorubicin. The mechanism involves binding to the minor groove of DNA, leading to alkylation of adenine residues via its propabenzindole (CBI) moiety, making it a valuable candidate for cancer research and therapeutic applications.
Chemical Information
| Catalog Num | A41035 |
|---|---|
| M. Wt | 550.01 |
| Formula | C31H24ClN5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 615538-51-7 |
| Synonyms | |
| SMILES | O=C(C(N1)=CC2=C1C=CC(N)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3 |
Biological Activity
| Description | DC0-NH2 is an effector moiety targeting antibody-drug conjugates (ADCs) with enhanced stability compared to its analog DC1. This compound exhibits remarkable cytotoxicity, demonstrating approximately 1000-fold greater potency than traditional anticancer agents like Doxorubicin. The mechanism involves binding to the minor groove of DNA, leading to alkylation of adenine residues via its propabenzindole (CBI) moiety, making it a valuable candidate for cancer research and therapeutic applications. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
