Product Data Sheet
Tubulysin G
Catalog No. A41080
Tubulysin G is a potent anti-microtubule toxin that targets microtubule dynamics by inhibiting tubulin polymerization. Derived from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin G exhibits significant cytotoxicity towards mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Its ability to induce apoptosis and cause cell cycle arrest makes it a valuable reagent for research applications in cancer biology and cell death mechanisms.
Chemical Information
| Catalog Num | A41080 |
|---|---|
| M. Wt | 842.05 |
| Formula | C43H63N5O10S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 799822-08-5 |
| Synonyms | |
| SMILES | O=C(N[C@@H]([C@@H](C)CC)C(N(COC(/C=C(C)/C)=O)[C@@H](C(C)C)C[C@@H](OC(C)=O)C1=NC(C(N[C@@H](CC2=CC=C(O)C=C2)C[C@H](C)C(O)=O)=O)=CS1)=O)[C@@H]3N(C)CCCC3 |
Biological Activity
| Description | Tubulysin G is a potent anti-microtubule toxin that targets microtubule dynamics by inhibiting tubulin polymerization. Derived from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin G exhibits significant cytotoxicity towards mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Its ability to induce apoptosis and cause cell cycle arrest makes it a valuable reagent for research applications in cancer biology and cell death mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
