Product Data Sheet
Tubulysin E
Catalog No. A41100
Tubulysin E is a potent apoptosis inducer that acts as an anti-microtubule toxin. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin E exhibits remarkable cytotoxicity in mammalian cells, including those resistant to multiple drugs, with calculated IC50 values in the low nanomolar range. The compound effectively disrupts microtubule dynamics by inhibiting tubulin polymerization, leading to cell cycle arrest and subsequent apoptotic cell death. This makes Tubulysin E a valuable tool in cancer research and studies focused on apoptosis mechanisms.
Chemical Information
| Catalog Num | A41100 |
|---|---|
| M. Wt | 814.04 |
| Formula | C42H63N5O9S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 309935-58-8 |
| Synonyms | |
| SMILES | CC(O[C@@H](C1=NC(C(N[C@H](C[C@H](C)C(O)=O)CC2=CC=CC=C2)=O)=CS1)C[C@H](C(C)C)N(COC(CCC)=O)C([C@@]([C@@H](C)CC)([H])NC([C@@H](CCCC3)N3C)=O)=O)=O |
Biological Activity
| Description | Tubulysin E is a potent apoptosis inducer that acts as an anti-microtubule toxin. Isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis, Tubulysin E exhibits remarkable cytotoxicity in mammalian cells, including those resistant to multiple drugs, with calculated IC50 values in the low nanomolar range. The compound effectively disrupts microtubule dynamics by inhibiting tubulin polymerization, leading to cell cycle arrest and subsequent apoptotic cell death. This makes Tubulysin E a valuable tool in cancer research and studies focused on apoptosis mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
