Product Data Sheet
Gly-Cyclopropane-Exatecan
Catalog No. A41103
Gly-Cyclopropane-Exatecan functions as a key component in the synthesis of antibody-drug conjugates (ADCs) targeting B7-H4. It incorporates Exatecan, a potent DNA Topoisomerase I inhibitor, into the ADC hu2F7-Exatecan, which has demonstrated significant antitumor efficacy in vivo and in vitro. This compound is relevant for cancer research, particularly in the development of targeted therapy strategies against tumor cells expressing B7-H4.
Chemical Information
| Catalog Num | A41103 |
|---|---|
| M. Wt | 619.64 |
| Formula | C32H34FN5O7 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2414254-49-0 |
| Synonyms | |
| SMILES | NCC(NCOC(C1CC1)C(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O |
Biological Activity
| Description | Gly-Cyclopropane-Exatecan functions as a key component in the synthesis of antibody-drug conjugates (ADCs) targeting B7-H4. It incorporates Exatecan, a potent DNA Topoisomerase I inhibitor, into the ADC hu2F7-Exatecan, which has demonstrated significant antitumor efficacy in vivo and in vitro. This compound is relevant for cancer research, particularly in the development of targeted therapy strategies against tumor cells expressing B7-H4. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
