Product Data Sheet
DSR-71167
Catalog No. A41164
DSR-71167 is an orally active mineralocorticoid receptor antagonist exhibiting an IC50 of 0.26 μM. This compound displays weak carbonic anhydrase inhibitory activity with an IC50 of 19 μM. DSR-71167 has demonstrated the ability to dose-dependently enhance urinary sodium excretion and effectively lowers systolic blood pressure in hypertensive rat models, while presenting a low risk of hyperkalemia in potassium-loading scenarios. It is suitable for research focused on hypertension and heart failure.
Chemical Information
| Catalog Num | A41164 |
|---|---|
| M. Wt | 529.96 |
| Formula | C23H23ClF3N3O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1355687-91-0 |
| Synonyms | |
| SMILES | O=C(C1=CC=C(C2=CC=CC=C2F)C(CNCC(F)F)=C1)NC3=CC=C(S(=O)(N)=O)C(OC)=C3.Cl |
Biological Activity
| Description | DSR-71167 is an orally active mineralocorticoid receptor antagonist exhibiting an IC50 of 0.26 μM. This compound displays weak carbonic anhydrase inhibitory activity with an IC50 of 19 μM. DSR-71167 has demonstrated the ability to dose-dependently enhance urinary sodium excretion and effectively lowers systolic blood pressure in hypertensive rat models, while presenting a low risk of hyperkalemia in potassium-loading scenarios. It is suitable for research focused on hypertension and heart failure. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
