Product Data Sheet
hCAIX-IN-11
Catalog No. A41195
hCAIX-IN-11 is a selective inhibitor of carbonic anhydrase IX (hCA IX) and XII (hCA XII), demonstrating Ki values of 32.7 nM and 623.5 nM, respectively. hCA IX and hCA XII are transmembrane isoforms that serve as biomarkers for various tumors, making them critical targets for cancer research. In addition to its role in tumor biology, hCA XII is involved in regulating acid-base homeostasis in both normal and cancerous cells, supporting its relevance in studies of metabolic regulation and tumor microenvironments.
Chemical Information
| Catalog Num | A41195 |
|---|---|
| M. Wt | 406.82 |
| Formula | C21H15ClN4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2497504-81-9 |
| Synonyms | |
| SMILES | N#CC1=CC=C(CN2N=NC(COC3=CC=C(C(O4)=C3)C(CCl)=CC4=O)=C2)C=C1 |
Biological Activity
| Description | hCAIX-IN-11 is a selective inhibitor of carbonic anhydrase IX (hCA IX) and XII (hCA XII), demonstrating Ki values of 32.7 nM and 623.5 nM, respectively. hCA IX and hCA XII are transmembrane isoforms that serve as biomarkers for various tumors, making them critical targets for cancer research. In addition to its role in tumor biology, hCA XII is involved in regulating acid-base homeostasis in both normal and cancerous cells, supporting its relevance in studies of metabolic regulation and tumor microenvironments. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
