Product Data Sheet
Chlorthalidone Impurity G
Catalog No. A41297
Chlorthalidone Impurity G is identified as a carbonic anhydrase inhibitor. This compound exhibits moderate antihypertensive effects and is found as a potential impurity in commercial preparations of chlorthalidone. Its primary mechanism involves the inhibition of the Na+/Cl- cotransporter in the kidney's distal tubule, leading to reduced sodium and chloride reabsorption, which ultimately decreases plasma volume and cardiac output. Additionally, it primarily inhibits carbonic anhydrase isoenzymes CAVB, VII, IX, XII, and XIII, with K_i values ranging from 2.8 to 23 nM, thereby contributing to its vasodilatory properties.
Chemical Information
| Catalog Num | A41297 |
|---|---|
| M. Wt | 294.13 |
| Formula | C14H9Cl2NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 16289-13-7 |
| Synonyms | Chlorthalidone EP Impurity G |
| SMILES | O=C1NC(O)(C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3 |
Biological Activity
| Description | Chlorthalidone Impurity G is identified as a carbonic anhydrase inhibitor. This compound exhibits moderate antihypertensive effects and is found as a potential impurity in commercial preparations of chlorthalidone. Its primary mechanism involves the inhibition of the Na+/Cl- cotransporter in the kidney's distal tubule, leading to reduced sodium and chloride reabsorption, which ultimately decreases plasma volume and cardiac output. Additionally, it primarily inhibits carbonic anhydrase isoenzymes CAVB, VII, IX, XII, and XIII, with K_i values ranging from 2.8 to 23 nM, thereby contributing to its vasodilatory properties. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
