Product Data Sheet
Mc-VC-PAB-SN38
Catalog No. A41321
Mc-VC-PAB-SN38 is a cleavable drug-linker conjugate that combines a linker (Mc-VC-PAB) with the potent DNA topoisomerase I inhibitor SN38. This compound is designed for the synthesis of antibody-drug conjugates (ADCs), providing a targeted approach for delivering therapeutic agents to malignant cells. Its unique structure facilitates the release of SN38 within the cellular environment, enhancing therapeutic efficacy while minimizing systemic toxicity.
Chemical Information
| Catalog Num | A41321 |
|---|---|
| M. Wt | 991.05 |
| Formula | C51H58N8O13 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1801838-28-7 |
| Synonyms | |
| SMILES | O=C1OCC(C2=O)=C(C=C(N2CC3=C(CC)C4=C5)C3=NC4=CC=C5O)[C@]1(CC)OC(OCC6=CC=C(C=C6)NC([C@@H](NC([C@@H](NC(CCCCCN7C(C=CC7=O)=O)=O)C(C)C)=O)CCCNC(N)=O)=O)=O |
Biological Activity
| Description | Mc-VC-PAB-SN38 is a cleavable drug-linker conjugate that combines a linker (Mc-VC-PAB) with the potent DNA topoisomerase I inhibitor SN38. This compound is designed for the synthesis of antibody-drug conjugates (ADCs), providing a targeted approach for delivering therapeutic agents to malignant cells. Its unique structure facilitates the release of SN38 within the cellular environment, enhancing therapeutic efficacy while minimizing systemic toxicity. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
