Product Data Sheet
MC-SN38
Catalog No. A41344
MC-SN38 is a drug-linker conjugate that combines the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for the development of antibody-drug conjugates (ADCs). SN38, a bioactive metabolite of the Topoisomerase I inhibitor Irinotecan, exerts its biological activity by inhibiting DNA synthesis and inducing DNA single-strand breaks. This compound is essential for research into targeted cancer therapies that leverage the specificity of antibodies to deliver cytotoxic agents to tumor cells.
Chemical Information
| Catalog Num | A41344 |
|---|---|
| M. Wt | 585.60 |
| Formula | C32H31N3O8 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1473403-87-0 |
| Synonyms | |
| SMILES | O=C(CCCCCN(C1=O)C(C=C1)=O)O[C@@](C(C=C(C2=NC3=CC=C4O)N5CC2=C(C3=C4)CC)=C6C5=O)(C(OC6)=O)CC |
Biological Activity
| Description | MC-SN38 is a drug-linker conjugate that combines the potent microtubule-disrupting agent SN38 with a non-cleavable MC linker, designed for the development of antibody-drug conjugates (ADCs). SN38, a bioactive metabolite of the Topoisomerase I inhibitor Irinotecan, exerts its biological activity by inhibiting DNA synthesis and inducing DNA single-strand breaks. This compound is essential for research into targeted cancer therapies that leverage the specificity of antibodies to deliver cytotoxic agents to tumor cells. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
